IVF-ICSI

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IVF-ICSI

Invitro Fertilisation ( IVF)& Intracytoplasmic Sperm Injection( ICSI )

Who may need IVF ?
We recommend in select cases after thorough evaluation.

Couples who failed to conceive after scientifically recommended number of simpler treatment cycles like ovulation induction , timed intercourse or IUI

Blocked or extremely damaged fallopian tubes despite corrective surgery

Unexplained infertility

Long duration of infertility

Women already above 37-38 years of age with addition poor prognostic factors

Fertility preservation in cases of cancer treatment or personal reasons

Couple with RIF , repeated abortion or genetic diseases who will need genetic test of embryos for PGT-A or PGT-D

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How IVF is done
The basic steps of IVF are –
1. Preparation before IVF -To improve oocyte & sperm quality
2. Ovarian Stimulation -Individualised hormonal treatment to woman to stimulate ovaries to produce 10-20 eggs.
3. Follicular monitoring -ultrasound & blood hormone analysis to evaluate oocyte quality & maturity.
4. Hormonal Trigger -for oocyte final maturation.
5. Oocyte Retrieval -To improve oocyte & sperm quality

- Aspiration of mature oocytes ( eggs) from ovarian follicles after 34-38 hours of trigger injection.

- It is done after oocyte maturation but before spontaneous follicle rupture inside body.

6. Fertilisation of egg :To improve oocyte & sperm quality

-This is the actual step for which the term IVF is used.

-In vitro means inside lab & fertilisation is fusion of egg & sperm.

-Husband’s semen is analysed & processed in lab to select best quality sperms & then mature oocytes(eggs) are fertilised with selected sperms inside lab.

Intracytoplasmic Sperm Injection :
  • ICSI is advanced modification of IVF to fertilise egg with sperm.
  • During ICSI each oocyte is held & injected individually with selected sperm by trained embryologist.
  • That is why the term ICSI- Intra Cytoplasmic ( of oocyte here ) Sperm Injection is used.
ICSI is preferred over IVF in following cases :
  • Woman with low number of eggs.
  • Men with very low number of sperms.
  • Men with poor sperm quality.
  • Men with poor sperm motility.
  • Men with sperm retrieved after TESA / micro TESA in cases of azoospermia.
  • Couple with previous partial or total fertilisation failure.
  • Couple using frozen sperms.
7. Embryo Culture :

-Fertilised egg is nurtured in highly controlled & enriched environment inside specialised incubators.

-During 3-5 days of growth embryos are assessed for quality.

8. Fresh Embryo Transfer :

-If women is fit for fresh embryo transfer then 1-2 good quality embryos are transferred inside uterus.

9. Embryo Cryopreservation :

- It is commonly called embryo freezing.

- Additional embryos after fresh transfer or all embryo in select cases are cryopreserved for future use.

10. Pregnancy test : is done 10-12 days after embryo transfer.
11. Thawed Embryo Transfer :

- -It is also called FET ( Frozen Embryo Transfer ).

- Cryopreserved embryos can be transferred in uterus later in couples who does not conceive after fresh embryo transfer or who wish to plan 2nd baby in future.

Hope this was helpful for basic understanding .The aim of this discussion is to make anyone with curious mind to understand these condition better .It is not equivalent to detailed in person individualised consultation .Please contact us if you want to understand your treatment options .