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  • It is the most commonly performed & the most successful type of IVF.
  • Here standard dose of hormone injections are given for 8-10 days so that 10- 20 follicles can grow for oocyte retrieval.
  • Woman with normal ovarian reserve & normal quality husband’s sperms are good candidate for conventional IVF.
Advantage :
  • We get more number of embryos which can be used to plan even 2nd pregnancy in future.
  • It can be ‘1 IVF cycle done & family completed’ for many couples.
Drawback :
  • Use of higher doses of medication ( additional cost ).
  • Risk of ovation hyper stimulation syndrome (OHSS) due to more number of growing follicles.
Natural cycle IVF is done without any hormone medication with the aim to collect naturally growing egg from the ovaries . Advantage
  • It can be used for woman who want ‘Drug Free IVF’.
  • It is cost effective in terms of medication cost
Drawback :
  • Risk of natural ovulation inside body before oocyte retrieval.
  • Low success rate as usually only 1 egg is collected.
  • It has a very high chance of cancelled treatment due to no egg retrieved at time of OCR .
In modified natural cycle IVF minimum medication are given to help collection of naturally growing eggs from the ovaries.
  • It can used for woman who wish to take minimum possible medication.
Drawback :
  • Low success rate as usually only 1 or 2 oocytes are collected.
In Mild IVF low doses of fertility medicines are given for 5 to 10 days to promote growth & collection of 2-5 eggs.
  • It can be used for women with low ovarian reserve, where ovaries can produce 2 to 5 eggs despite maximum those of fertility medication.
  • So, choosing for mild IVF in such cases reduces cost of medication & also emotional burden of the treatment.
Drawback :
  • Lesser success chance per started cycle as lesser number of oocytes & embryos are available.

Normally a matured oocyte called Metaphase 2 ( M2 ) oocyte is released from ovary at the time of ovulation. Similarly, during routine IVF procedure matured oocyte is collected from the ovaries.

In IVM process immature eggs ( Germinal vesicle & metaphase1 ) are collected from the ovaries & then matured inside incubator in embryology laboratory. This is why it is called In Vitro Maturation ( IVM ).

In Vitro Matured egg is then used for ICSI.

  • It can be used for women with Polycystic Ovarian Disease to avoid risk of ovarian hyperstimulation.
  • Women who want fertility preservation before starting treatment for cancer, but have very limited time ( only few days ) can opt for IVM of oocytes & IVF/ICSI.
Drawback :
  • It has lesser success per started cycle as compared to conventional IVF. .

In IVF & ICSI both processes semen sample is processed to separate healthier fraction of sperms .

During IVF process sperms are incubated overnight in culture dishes with aspirated mature oocytes . Here fertilization takes place naturally.

ICSI is advanced modification of IVF .

During ICSI each oocyte is held & injected individually with selected sperm by trained embryologist . That is why the term ICSI- Intra Cytoplasmic ( oocyte cytoplasm ) Sperm Injection is used

ICSI is preferred over IVF in following cases :
  • Woman with low number of eggs.
  • Men with very low number of sperms.
  • Men with poor sperm quality.
  • Men with poor sperm motility.
  • Men with perm retrieved after TESA / micro TESA in cases of azoospermia.
  • Couple with previous partial or total fertilisation failure.
  • Couple using frozen sperms.